Fluidigm
Integrated Fluidic Circuits
Accelerate and Enable
FLUIDIGM TECHNOLOGY
Biotechnology promises to become the defining technology of the 21st century. Continued development of the industry fundamentally depends on new tools that can deliver miniaturization and integration-just as the integrated circuit gave rise to the computer age.
Today, with MSL™ technology tens of thousands of fluid control valves and interconnected channels are fabricated within miniature devices. We call these devices integrated fluidic circuits (IFCs) because, like their analog in the semiconductor industry, they are networks of discrete pathways and intermediate switches. Instead of electrons, they move molecules of biological samples and reagents in a dazzling variety of patterns.
IFCs are the core technology in Fluidigm's product portfolio of:
- The BioMark HD and Biomark Systems
- The Access Array System
- The EP1 System
- The TOPAZ System
- Chips and Kits
NEW! THE BIOMARK™ HD SYSTEM
The BioMark™ HD System provides you with the ability to use a wide variety of sample types, multiple chemistry choices, and an industry leading degree of flexibility. The system offers unparalleled throughput for real-time PCR and digital PCR, integrating thermal cycling and fluorescence detection on Integrated Fluidic Circuits (IFCs).
Integrated Fluidic Circuits significantly improve productivity in life science research by enabling the simultaneous performance of PCR reactions in nanoliter volumes. This is made possible by miniaturizing and integrating liquid handling components on a single microfluidic device. The BioMark HD System consists of a real-time PCR instrument, Dynamic Array™ IFCs for multiplexing the samples and reagents, as well as an IFC loader to load the Dynamic Array IFCs.
Key Applications include:
- Gene Expression
- Single Cell Gene Expression
- SNP Genotyping
- Copy Number Variation
- Sample Quantification for Sequencing
The BioMark™ HD System is the newest real-time PCR system developed by Fluidigm. With enhanced productivity, increased reliability, and a smaller footprint, the BioMark HD System gives you everything the original BioMark delivered-and more.
Increase confidence - reproducible results from populations of cells down to a single cellSave time and money - fast PCR-enabled, nanofluidic technology allows you to collect more data points per day at less cost than 384-well systemsExpand your possibilities - ability to use multiple reagents and different sample and assay configurations.
Download the BioMark HD brochure and contact us for more information.
THE BIOMARK SYSTEM
The BioMark™ line of life science products are meeting the challenges of today's high throughput research environment through integrated fluidic circuits known as dynamic arrays and digital arrays. These innovative products allow scientists to practice tried-and-true techniques, such as TaqMan® assays, while realizing a previously unachievable throughput.
The advantages of the BioMark system include:
- Savings. Researchers save on reagents, pipette tips, time, and on the upkeep of expensive liquid-handling robots.
- More Data. Far more data are generated compared to microwell chips, and with no pre-spotting required.
- Throughput. Each 96.96 Dynamic Array is capable of producing 9,216 real-time qPCR data points in the same amount of time as a single 384-well plate, while using just 1/200th the amount of reagents.
THE ACCESS ARRAY SYSTEM
Introducing the Superior Sample Preparation System for Next-Generation Sequencing
The Access Array™ Integrated Fluidic Circuit (IFC) facilitates parallel amplification of 48 unique samples, in effect preparing 48 sequencing libraries, in just a few hours. Every reaction combines both an amplicon tagging and a barcoding (identification) step that enables all 48 amplicons to be multiplexed at the sequencing step. This powerful chemistry simplifies the up-front preparation and maximizes the utility of today's next generation sequencers.
The Fluidigm Access Array System can be used with any PCR-based sample preparation method and with the reagents and primers of your choice. The system includes Access Array IFCs-single-use microfluidic chips-two IFC Controller AXs, and the Stand-Alone Thermal Cycler that easily deliver sample throughput and coverage that scale with laboratory needs.
THE EP1 SYSTEM
The Fluidigm EP1 system for genetic analysis enables high-throughput SNP genotyping and end point digital PCR research through integrated fluidic circuits (IFCs) known as dynamic arrays and digital arrays. These innovative products allow scientists to practice tried-and-true techniques, such as TaqMan® assays, while realizing a previously unachievable throughput.
The advantages of the EP1 system include:
- Outstanding Data Quality
- 99%+ Call rates
- 99.75% Accuracy in SNP genotyping experiments
- Fast and Easy Workflow
- 200K+ Genotypes in one day
- About 100x Fewer pipette steps
- Cost Effective System
- About 100x Lower reagent volume requirements
- About 100x Fewer pipette tips
THE TOPAZ SYSTEM
The TOPAZ system for protein crystallography provides a complete screen-to-beam solution.
- High quality in situ diffraction-based screening of crystals
- The lowest sample volume requirements
- The most accurate crystal calling software in the industry
The TOPAZ system sets new standards for efficiency in protein crystallization. It consists of chips, hardware and software that simplify and automate nanoscale free interface diffusion (FID). The family of chips includes the 1.96 Diffraction Capable (DC) chip-which uniquely provides early access to high quality in situ X-ray diffraction data-and the 4.96 screening chip-which provides the ideal solution for ultra low volume, parallel screening.
CHIPS AND KITS
Chips
Push the limits of efficiency using our unique integrated fluidic circuits (IFCs). Learn about the advantages of IFCs for your application.
FLUIDIGM® DIGITAL ARRAY
The Fluidigm Digital Arrays-48.770 and 12.765-provide a practical solution for PCR applications demanding extreme accuracy of copy number.
FLUIDIGM® DYNAMIC ARRAYS
The Fluidigm Dynamic Arrays-96.96 and 48.48-maximize efficiency for gene-expression analysis and genotyping.
PROTEIN CRYSTALLIZATION
TOPAZ® Screening Chips are the new standard for efficiency in protein crystallization.
Kits
Unleash the power of our unique integrated fluidic circuits (IFCs). Learn about the advantages of using our kits for your application.
NEXT GEN SEQUENCING FOR DNA SEQUENCING
The SlingShot™ Kit for sequencing quickly and easily determines the concentration of your DNA library, with absolute accuracy.
About Fluidigm
Fluidigm develops, manufactures and markets proprietary Integrated Fluidic Circuit (IFC) systems that significantly improve productivity in life science research. Fluidigm IFCs enable the simultaneous performance of thousands of sophisticated biochemical measurements in extremely minute volumes. These "integrated circuits for biology" are made possible by miniaturizing and integrating liquid handling components on a single microfluidic device. Fluidigm systems, consisting of instrumentation, software and chips, increase throughput, decrease costs and enhance sensitivity compared to conventional laboratory systems.
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