Dharmacon Reagents - Advancing Functional Genomics Research
Dharmacon Reagents provide researchers with a comprehensive portfolio of tools to explore gene function at the DNA, RNA and protein levels. With one of the most extensive selections of functional genomics technologies available, Dharmacon supports both targeted gene studies and genome-wide screens. Their solutions are designed to help scientists unravel complex biological pathways and drive discoveries in genetic research and therapeutic development.
With nearly 30 years of expertise, Dharmacon is recognised as a leader in synthetic oligonucleotides. They were the first to introduce algorithm-designed synthetic siRNA for RNA interference (RNAi) and among the first to develop guide RNAs for CRISPR-Cas9 genome editing.
Explore Dharmacon’s legacy of innovation and discover how their reagents can support your functional genomics research.
Download the infographic to learn more about Dharmacon’s innovation journey.
Dharmacon™ siRNA solutions
ON-TARGETplus™ siRNA
These siRNAs feature a patented dual-strand modification pattern for greater specificity and minimal off-target effects. ON-TARGETplus™ siRNAs are the premium choice for guaranteed gene silencing and functional genomics studies.
Available product formats:
- SMARTpool: A mixture of 4 siRNA provided as a single reagent; providing advantages in both potency and specificity.
- Set of 4: A convenient option for purchasing aliquots of all 4 individual siRNAs targeting a single gene.
- Individual siRNA
Accell™ siRNA
Self-delivering siRNAs that do not require transfection reagents, viral vectors or instruments for delivery. Simplifies the workflow for gene silencing in hard-to-transfect cells. Accell™ siRNA works at a higher concentration (1µM ) than conventional siRNA. Suitable for in vivo studies and primary cultures.
Available product formats:
- SMARTpool: A mixture of 4 siRNA provided as a single reagent; providing advantages in both potency and specificity.
- Set of 4: A convenient option for purchasing aliquots of all 4 individual siRNAs targeting a single gene.
- Individual siRNAs: Select 1, 2, 3, or 4 individual siRNAs per gene.
siGENOME™ siRNA
A reliable siRNA product line known for its consistent performance in gene silencing. Widely used in various research applications. Offers a broad selection of pre-designed siRNAs for human, mouse, and rat genes.
Available product formats:
- SMARTpool: A mixture of 4 siRNA provided as a single reagent; providing advantages in both potency and specificity.
- Set of 4: A convenient option for purchasing aliquots of all 4 individual siRNAs targeting a single gene.
- Individual siRNAs: Select 1, 2, 3 or 4 individual siRNAs per gene.
Customer Insight
“We use the SMARTvector Inducible shRNA constructs extensively in our research for both in vitro functional assays and in vivo mouse models. They have given us precise control over gene expression in all of these models, allowing us to explore a number of potential drug targets for the treatment of metastatic breast cancer.”
Associate Professor David Croucher
Lab Head, Garvan Institute of Medical Research
