Human Structural Variant Analysis

Fix-C and Dovetail Hi-C with Selva for Insights into human disease

You've been looking for a better way to understand the underlying genomics of human disease. It's here now.  
Seeing and resolving all classes of structural variation is one of the biggest challenges in human disease.
T
here is a growing focus on large structural variants and their role in cancer and other diseases. Current technologies can find structural variants you already know exist, or only identify variants from some classes, such as copy number variations.

What you've been missing is a tool that can find and resolve all classes of large structural variants, including balanced and complex variants, across the entire genome. You can see past the barriers with Fix-C™ for FFPE and Dovetail™ Hi-C for all other sample types. We've demonstrated a mastery of proximity ligation in our market-leading services for genome assembly. Now we've fine-tuned it to detect large structural variants and 3D features that other methods cannot see. With results from Selva™ analysis, you'll be able to see the full spectrum of genomic features—from actionable variants to features that have never been described—at a level of complexity that's unprecedented. We believe the impact on cancer and other human disease research will be enormous.

FFPE is the de facto archival material for biopsy specimens. For the first time, we can help you see structural variants and 3D features on a genome-wide scale in FFPE.

Think of how many decades of paraffin-embedded biopsy specimens are available in research facilities. How much further could you advance disease research if there was a way to learn more from them? We're giving you the ability to do just that with Fix-C™ and Selva™ analysis. Reveal previously undetectable structural variants and 3D chromatin features in FFPE samples, and take your research—and our global understanding of the genome—to a whole new level.




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Human Genome Profiling




Hi-C

Dovetail™ Hi-C Kits make running Hi-C in your lab easier than ever

Researchers are increasingly interested in Hi-C data, but significant challenges remain to establishing and maintaining a Hi-C assay in a lab. Available Hi-C protocols are time-intensive and have historically required substantial troubleshooting. The Dovetail™ Hi-C Library Preparation kit has been optimized through Dovetail's in-house Hi-C service. The kit comes with the reagents needed to create Illumina® sequencing-ready libraries. The protocol is extremely robust. In a validation study 100% of samples generated high-quality Hi-C sequencing libraries. The protocol has also been optimized to simplify and shorten the work flow, supporting sample to sequencing-ready library in just 2 days, greatly reducing the obstacles to running the Hi-C assay in your lab.

Dovetail™ Hi-C kit and HiRise™ software are integrated and optimized for genome assembly

The best approach for generating high-quality assemblies is optimizing the molecular biology technique and scaffolding software together specifically for genome assembly. Until now, for the Hi-C data type, there were no integrated, optimized and commercially available genome scaffolding solutions for the lab. Dovetail, through its services group, has actively optimized the Dovetail™ Hi-C molecular biology protocol and HiRise™ pipeline with more than a 1000 genomes scaffolded to date. The integrated and optimized Hi-C assembly service has been encapsulated into the Dovetail™ Hi-C library preparation kit and HiRise™ software now directly available to labs.

Features

  • Capture Megabase range information with Dovetail's proximity ligation technology
  • Generate chromosome-level assemblies with HiRise™, the leading proximity ligation genome scaffolding software
  • Dovetail quality assemblies in your lab; optimized end-to-end from the world's leading service
  • Makes running Hi-C in your lab easier than ever with robust sequencing-ready libraries and high quality Hi-C data
  • Assemble more genomes to answer more biological questions with a lower cost per sample, on your own schedule
  • The convenience of a single kit for all genomes from plants to a wide variety of animals

Workflow



Fix-C

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Selva

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