Laboratory Workcells

Below is a list of solutions Hudson have developed to automate various processes in the biological, drug discovery and medical fields. Hudson develop automated robots, laboratory equipment systems, and machines for streamlined automation of various lab processes.

Product List




DNA Extraction Systems (DNA, RNA and Proteins)

extraction_choices.jpgHudson Robotics has introduced an automated DNA extraction system as another member of their expanding catalog of powerful systems designed to support genetic research efforts. The DNA extraction system greatly simplifies the process of isolating pure nucleic acids and/or proteins from a wide variety of natural sources.  
These laboratory workcells are built around our PlateCrane EX™ or our SciClops™ robot arm for hours of hands-off processing time. The workcells can utilise Hudson's family of liquid handling instruments or 3rd party manufactures liquid handling instruments which all can be controlled by our powerful SoftLinx automation software.


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ProLink Express

automated-proteomics-workcell-prolink-express.jpgThe ProLink Express represents a breakthrough in integrating laboratory instruments that has changed the way researchers use automation. It is the first fully automated proteomics workcell that integrates all plate delivery and transfer operations with complete data tracking. It automates the entire protein expression process, from initial bacterial colony picking through final protein expression and measurement. The ProLink Express system is capable of delivering a plate to any of its instruments from any other instrument, in any order and simultaneously with other processes.

The ProLink Express is designed so that colony picking, growth, DNA prep and expression can be run individually or sequentially. All instrumentation faces outward so any component can be used manually and it is powered by our opportunistic SoftLinx scheduling software, which finds the most efficient ways to perform processes simultaneously. A user can run multiple batches in different stages of the process at the same time, or run any instrument individually while operating another, fully automated run.


Features

  • Optimises laboratory processes and equipment usage
  • Designed to fit into available lab space
  • Allows independent as well as manual access to and operation of all major system instruments
  • Capable of delivering a plate to any of its instruments from any other instrument, in any order and simultaneously with other processes

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VaryScreen™ I Multi-Assay Screening System

assay-screening-and-development-varyscreen-300x253.pngVaryScreen I integrates laboratory instrumentation with plate and liquid handling robots and software to automate all aspects of an assay. The basic configuration includes a multimode microplate reader with fluorescence, luminescence, and UV-Visible detectors. The system's SoftLinx software controls all of the robot's actions in an efficient, coordinated operation.


Features

  • Evaluate subtle changes in experimental conditions
  • Determine importance of individual steps
  • Introduce intelligence into protocols
  • Schedule e-mail alerts or responses to specific milestones
  • Includes 6 general pre-written protocols to get you started



VaryScreen ADME-Tox System

Biochemical Assay Support VaryScreenHudson's integrated screening workcell is designed to provide quick and accurate profiling of ADME and toxicological properties of drug molecules. The basic system contains everything needed to support biochemical assays that measure physicochemical properties of drug molecules, such as solubility, lipophilicity, pKa and protein binding, and also supports PAMPA and CACO2 permeability assays. It also can measure a drug's affinity towards key toxicological targets, such as hERG, and the various CYP metabolic enzymes.

The system is controlled by Hudson's SoftLinx scheduling software, and comes with sample protocols for each of the included ADME/Tox methods. These can be easily modified, or more assays can be added to further customise your follow-up screening efforts. The system comes with a multi-mode reader that not only supports a wide range of protocols, but can also run your primary or secondary screens. This means that you can have your ADME/Tox profiling automatically carried out on hits found in these assays.





Automated ELISA Workstation

elisahood.jpgThe workstation shown to the left supports ELISA assays as well as serial dilutions to study concentration-dependent effects. The version depicted in the picture is equipped with a 12-channel, 200uL pipette head that can move liquid between the 5 available nest positions on the deck of the SOLO as well as to pipette into the nests on the Micro10x and the RapidWash. In this layout, the deck of the SOLO contains a rack of disposable tips, a deep-well reagent reservoir and a rack of Matrix tubes containing samples. The SOLO moves aliquots of samples into the first row of the 96 well plate on the Micro10x nest, and the dispenser then fills the remaining 11 rows with diluent as the first steps of a serial dilution of the 12 samples. The pipette head then carries out a serial dilution by systematically aspirating, mixing and dispensing down the rows. The SOLO next adds reagents and aliquots of the serial dilution to the ELISA assay plate on the deck of the RapidWash, which then carries out a series of wash steps.  Between plate washing steps, the SOLO can pipette other reagents/antibodies into the plate, for multiple addition, incubation and wash cycles that may be required in the ELISA being performed. When the plate is finally ready for the plate reader, the workstation will email the user to move the plate into the plate reader, then place another assay plate onto the RapidWash nest, to begin the process for 12 more samples. When 96 samples have been prepared, the user can simply replace the Matrix tube rack with another rack of sample tubes, replace the disposable tip rack with a new one, then begin the process again.





Rapid_pH Automatic pH Meter

Trapid_ph-pic-300x239.png he Rapid_pH™ pH meter reduces  the time and tedium associated with  manual  pH testing .   Manual use of  a pH meter typically requires endless  rinsing, drying, immersing, waiting for stabilisation and recording of the result . The Rapid_pH pH reader makes your life so much easier by completely automating all of these steps at the press of a single click.
Your samples can be placed on the Rapid_pH meter in microplate format – up to 96 samples at a time, plates or tubes. Not only is the pH of  all of your samples measured quickly, but your accuracy and precision will be greatly improved. The accompanying reader software makes it extremely simple to calibrate the Rapid_pH probe with standard buffers. Once calibrated, the results of the pH probe have an accuracy of +/- 0.05 pH units and standard deviation of +/- 0.01. Hudson Robotics is using the Mettler Toledo InLab Micro pH probe which can be purchase directly from Hudson or from multiple labware distributors. The Mettler Toledo InLab Micro pH probe is capable of measuring pH in volumes as small as 45 ul. Hudson Robotics recommends a minimum of 75 ul in half well microplates due to potential differences between microplates.


Features

  • User friendly Rapid_pH software
  • Increase throughput of pH testing
  • Accurate to +-0.05 pH
  • Automated assures consistency of pH results
  • Measurement range from pH 0.0 to 14.0
  • Fast pH probe calibration
  • Manually add descriptions of pH samples
  • Import well by well pH sample descriptions from .CSV files
  • Export pH Sample Data in multiple formats
  • Capture user name, date, time and other notes in pH result files
  • Export calibration log files instead of manually logging pH calibration information
  • Completely automated protocol, requires no user intervention during operation



Synthetic Biology Workstation

synthetic-biology-workstation-web-e1433885995430.jpgHudson's new Synthetic Biology Workstation automates the entire portion of the pipeline from Gene Assembly through Plasmid Preparation. You provide the competent cells and the DNA Constructs, and the Synthetic Biology Workstation will do the rest. The software tracks everything from start to finish. DNA is normalized and transformations carried out. Agar is spread on Omni trays and colonies are plated to your specifications





Plasmid Prep Workcell

plasmidprep.pngThis small Plasmid Prep workcell supports standard miniprep protocols and includes a SOLO automated pipettor, a FilterPress automated 96 well filter plate positive pressure manifold, and a microplate shaking nest. High throughput can be added by including a PlateCrane robotic arm and microplate hotels.





OB-1 Robotic Lab Assistant

ob1-300x225.jpg A collaborative effort between Hudson Robotics and Obotics, this workcell supports a wide variety of sample preparation functions, including SPE/SLE processing, hydrolysis and derivativisation, with all of the requisite microplate and liquid handling features required to automate the entire process.


Features

  • Holds factory calibration for >50 million cycles
  • Self-priming
  • Handles any SBS standard microplate
  • Works with lidded or unlidded plates
  • No training required, ready to go to work right out of the box
  • Dispenses as little as 2ul
  • Adjustable in 10nl increments
  • Self-calibration

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RapidHit

hitpick.jpgHudson's RapidHit™ Simultaneous Automated HitPicking System is a compact, self-contained system that allows users to obtain assay plates comprised of the actual hits detected in a primary screen using the same compound source plates that provided the primary screen. The RapidHit uses the output files produced by the plate reader as they become available, and automatically selects and transfers "hits" based on user-entered criteria. As each primary screen assay plate is finished, the RapidHit immediately moves the hits to a secondary assay "hit plate", and completely eliminates the possibility of receiving the wrong compounds in secondary screening plates.

The RapidHit saves the need to return to the users compound storage library to run secondary or conformational screens of the hits in a primary screen. The hit-picked plates are prepared even while the primary screen is taking place, so the secondary or conformational screen can go forward without any delay. And, because the original source compound plates are being used, the secondary assay uses the same compound conditions as the primary screen. This eliminates any artifacts that may result from preparing secondary assay plates anew from the compound library



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