Dharmacon RNAi products encompass the most complete portfolio of innovative tools for transient, long-term, inducible and in vivo RNAi applications. The RNAi reagents are complemented with a complete suite of products for delivery, control and confirmation of results.
Complete your experiment with all necessary ancillary regents, including buffers, water, and specialized cell culture media.
5x siRNA Buffer is appropriate for resuspension and long-term storage of any short, doublestranded or single-stranded synthetic RNA molecule, including modified and unmodified siRNAs, microRNA Mimics and microRNA Hairpin Inhibitors. Dilute with RNase-free water prior to use.
It is critical to ensure ENase-free conditions to prevent degradation when working with RNA reagents. Molecular Grade RNase-free water is for dilution of 5x buffer or resuspension of RNA.
Accell siRNA requires low-serum or serum-free application conditions. Accell siRNA Delivery Media is an enriched, serum-free medium specially formulated and optimised for use during Accell siRNA delivery to maintain cell viability.
DharmaFECT Cell Culture Reagent (DCCR) is used to dilute DharmaFECT siRNA Transfection Reafent prior to use in Reverse Transfection Format (RTF) siRNA library plates.
RNase-free Tris-HCI supplied at the pH 7.4 and 10 mM concentration for easy resuspension of synthetic crRNA and tracrRNA molecules.
Up-regulate or suppress endogenous mature microRNA function with rationally designed synthetic and expressed microRNA modulation reagents. Best-in-class microRNA modulation tools including miRIDIAN microRNA Mimics, microRNA Hairpin Inhibitiors and shMIMIC Lentiviral microRNAs.
Fast and easy online configuration and ordering of plated siRNA & microRNA reagents targeting your genes of interest.
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Supplement endogenous microRNA activity to study gain-of-function effects. Premium design attributes promote strand-bias and enhance functionality.
Cherry-pick RNAi Libraries
Fast and easy online configuration and ordering of plated siRNA & microRNA reagents targeting your genes of interest.
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Custom microRNA Modulation Tools
Modify an existing microRNA mimic or inhibitor, target a novel microRNA, or request and Accell microRNA Inhibitor or Stabilised Mimic for special applications.
miRIDIAN microRNA Libraries
Mimic and Hairpin Inhibitor libraries are available for human, mouse, and rat microRNAs. provided in 96-well plates for high-throughput phenotypic screening.
miRIDIAN microRNA Mimic Controls
A complete portfolio of positive and negative experimental controls to optimise conditions and design relevant microRNA modulation experiments.
Innovative microRNA inhibitor design suppresses microRNA activity to study loss-of-function effects and allows for superior potency and longevity.
Cherry-pick RNAi Libraries
Fast and easy online configuration and ordering of plated siRNA & microRNA reagents targeting your genes of interest.
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Custom microRNA Modulation Tools
Modify an existing microRNA mimic or inhibitor, target a novel microRNA, or request and Accell microRNA Inhibitor or Stabilised Mimic for special applications.
miRIDIAN Hairpin Inhibitor Controls
A complete portfolio of positive and negative experimental controls to optimize conditions and design relevant microRNA modulation experiments.
miRIDIAN microRNA Libraries
Mimic and Hairpin Inhibitor libraries are available for human, mouse, and rat microRNAs. provided in 96-well plates for high-throughput phenotypic screening.
The industry's most innovative mature microRNA expression system combined with latest generation of powerful Tet-inducible technology.
Tight control of microRNA expression for powerful functional screening of hundreds or thousands of microRNAs.
Expressed lentiviral microRNAs with 7 promoter and 3 reporter options for optimal, integrated expression of mature microRNAs in difficult-to-transfect cells.
Perform functional screening of hundreds or thousands of microRNAs without high-throughput automation.
Critical to any gene silencing or microRNA modulation experiment, RNAi controls enable accurate interpretation for reliable, reproducible results. Everything you need for high-quality, reproducible results. Choose from negative and positive controls as well as transfection indicators for all product lines.
Effectively optimise Accell siRNA delivery conditions and control for variable in ongoing experiments with fluorescent or unlabeled positive and negative controls. Accell Control Kits combine species-specific validated controls for assessment of Accell technology in your difficult-to-transfect cells.
Validated collection of FIPZ positive and negative controls for a well-designed RNAi experiment. Available as glycerol stocks or viral particles.
Lincode Control siRNA reagents inforporate specificity-enhancing modifications to improve experimental results. Endogenous IncRNA positive control and non-targeting control siRNA and pool reagents for high-confidence experiments.
Critical to any successful microRNA modulation experiment, the right controls enable accurate interpretation for reliable results. Choose from a collection of validated positive and negative miRIDIAN Mimic controls for use in human, mouse or rat. Fluorescently labeled controls are also available for visual tracking.
Critical to any successful microRNA modulation experiment, the right controls enable accurate interpretation for reliable results. Choose from a collection of validated positive and negative miRIDIAN Mimic controls for use in human, mouse or rat. Fluorescently labeled controls are also available for visual tracking.
Validated positive controls and non-targeting negative controls utilizing patented modifications for optimal specificity. Available as pools or single siRNAs. ON-TARGETplus Control siRNAs and pools are produced with the patented ON-TARGETplus modification pattern for optimal specificity. They are recommended as controls for any siRNA experiment due to their minimized off-target effects.
RNAi experiments in vivo requiring stabilized siRNA molecules are supported by our panel of siSTABLE controls. Choose from siSTABLE-modified controls, siRNA for silencing reporter genes (GFP, Luciferase, etc.) or other experimental needs.
A robust selection of validated positive, negative, and novel RISC-Free® controls to effectively assess all aspects of RNAi experiments. Controls are critical for the successful applications of RNAi. Including the appropriate controls in each experiment adds certainty to the cause-an-effect relationship between gene silencing and siRNA, and aids in the distinction between target-specific and potential off-target effects.
Fluorescent controls are useful for visual indication of delivery, and when combined with functional knockdown assessment, provide a useful tool for optimisation. Choose from positive control siRNAs or our novel transfection indicators.
Matched Controls enable accurate data interpretation for both SMARTvector Inducible shRNA and shMIMIC Inducible microRNAs. Inducible expression of positive and negative controls with your choice of four promoters and two reporters.
Matched Controls enable accurate data interpretation for both SMARTvector shRNA and shMIMIC microRNAs. Positive and negative shRNA controls with choice of seven promoters and two fluorescent reporters. Available for human, mouse and rat.
TRC positive and negative shRNA controls for a well-designed gene silencing experiment. Positive shRNA control targeting GFP and empty lentiviral vector negative control available as glycerol stocks.
Positive and negative TRIPZ Inducible Lentiviral shRNA Controls for setting the experimental window. Inducible shRNA positive and non-targeting negative controls are available as glycerol stock or viral particles.
Accelerate discovery with the widest selection of RNAi screening collections available. Choose from whole genome, gene families, or custom libraries.
Choose from the pre-designed product lines of shRNA and over-expression reagents to build your own custom library.
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Fast and easy online configuration and ordering of platedsiRNA & microRNA reagents targeting your genes of interest.
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Duet siRNA Libraries offer paired siGENOME and ON-TARGETplus SMARTpool reagents in pre-defined collections for high-confidence siRNA screening. Screen them together or use them separately to support a wide range of RNAi discovery efforts.
Choose from GIPZ whole genome or gene family libraries for human or mouse. Pre-defined libraries have been assembled using innovative bioinformatic tools to reflect the most up-to-date genetic and ontological information. All libraries are offered as glycerol stocks of shRNA clones arrayed in 96-well plates. Perform genome-scale shRNA screening experiments with GIPZ Lentiviral shRNA libraries. Choose a pre-defined gene family library for smaller screening projects.
Human siRNA libraries are available in SMARTpool or individual siRNA format for ON-TARGETplus, siGENOME and Sccell technologies. learn more about each product line to make the right choice for your experimental needs. GE Dharmacon supports more strategies for successful screening and more screening expertise than any other provider.
Unbiased RNAi screens have become an important tool for elucidation of novel biological pathways and disease progression. The assessment of potential roles for microRNA and lncRNA, in addition to protein-coding genes, can provide a more complete picture of the genes involved in the phenotype of interest.
Cherry-pick libraries
Lincode siRNA reagents available as plated libraries for any customer-defined collection of IncRNAs of interest.
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Human NR IncRNA Library
3430 total long noncoding RNA gene targets containing at least one NR accession number, includes siRNAs targeting NR transcripts within protein coding genes.
Mouse NR IncRNA Library
1997 total long noncoding RNA gene targets containing at least one NR accession number, includes siRNAs targeting NR transcripts within protein coding genes.
miRIDIAN microRNA Mimic and Hairpin Inhibitor libraries are available for human, mouse and rat microRNAs in the miRBase sequence database. Libraries are packaged in 96-well plates for high-throughput screening applications. miRIDIAN tools are carefully designed to enhance functionality, specificity, and duration of action.
Mouse siRNA libraries are available in SMARTpool or individual siRNA format for ON-TARGETplus, siGENOME and Accell technologies. Learn more about each product line to make the right choice for your experimental needs. GE Dharmacon supports more strategies for successful screening and more screening expertise than any other provider.
Investigate thousands of genes with a single transduction event with powerful multiplexed screening tools.
SMARTvectory Lentiviral shRNA Pooled Libraries
Constitutive shRNA expresssion for optimised functional analysis screens.
SMARTvector Inducible Lentiviral shRNA Pooled Libraries
Inducible shRNA expression for regulatable and controlled functional analysis screens.
shMIMIC Lentiviral micrornA Pooled Libraries
Perform functional screening of hundreds or thousands of microRNAs without high-throughput automation.
shMIMIC Inducible Lentiviral microRNA Pooled Libraries
Tight control of microRNA expression for powerful functional screening of hundreds or thousands of microRNAs.
SMARTvector Indexing PCR and Sequencing Primer Kit
For use with SMARTvector and shMIMIC pooled libraries on Illumina systems.
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Reverse Transfection Format (RTF) siRNA libraries are provided as multiple single-use plate sets - just rehydrate and add cells. This unique pre-plated format reduces hands-on time for faster screening results.
Choose from TRC whole genome or gene family libraries for human or mouse. Pre-defined libraries have been assembled using innovative bioinformatic tools to reflect the most up-to-date genetic and ontological information. All libraries are offered as glycerol stocks of shRNA clones arrayed in 96-well plates.
Human gene families and a genome-wide collection available with an inducible promoter for the study of essential gene function.
Enzymatically generated custom siRNA libraries for screening in non-human or mouse model organisms. Enjoy algorithm-designed siRNA produced with a novel enzymatic method to support large functional genomics studies in non-human or mouse models.
SMARTvector, GIPZ, TRIPZ and TRC lentiviral shRNA products designed for optimal gene silencing. Choose from viral vectors, viral particles or viral pools. Dharmacon lentiviral shRNA products encompass the industry's broadest, most technologically advanced portfolio of vector-based RNAi reagents for transient, long-term, inducible, and in vivo RNA interference in human, mouse, and rat cells.
Designed using microRNA scaffold-specific attributes for highly efficient processing via the endogenous RNAi pathway while minimizing off-target potential.
SMARTvector Lentiviral shRNA
Advanced rationally-designed microRNA-based shRNA for human, mouse, and rat genes. Choose from seven constitutive promoters and three reporter options to tailor SMARTvector shRNA for specific cells.
SMARTvector Inducible Lentiviral shRNA
All the benefits of SMARTvector lentiviral shRNAs combined with latest generation of powerful Tet-inducible technology for unprecedented control over gene silencing and reduced off-targeting.
GIPZ Lentiviral shRNA
Efficient gene silencing with a microRNA-adapted shRNA design. Available as lentiviral vector constructs or high-titer lentiviral particles for human and mouse.
TRIPZ Inducible Lentiviral shRNA
Inducible shRNA expression allows for tightly regulatable RNAi experiments. Available as lentiviral vector constructs for human.
SMARTvector Lentiviral shRNA Pooled Libraries
High-titer pooled screening libraries of constitutive shRNAs for pre-defined gene libraries in human, mouse, and rat.
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Offers a classic hairpin, rules-based shRNA design utilizing a simple hairpin of 21 base pair sense and antisense stem, and a 6 basepair loop.
TRC Lentiviral shRNA
Lentiviral shRNA collection from The RNAi Consortium (TRC) with coverage in human and mouse.
Dharmacon siRNA products are the result of scientific innovation in siRNA design and novel modification strategies to optimize potency, specificity and delivery. Pre-designed genome-wide reagents for siGENOME, ON-TARGETplus, and Accell product lines. Choose highly potent siRNAs for human, mouse, and rat.
Specially modified for delivery into difficult-to-transfect cells without a transfection reagent, Accell enables non-viral RNAi in neuronal, immune, and stem cells.
Accell siRNA Controls
Effectively optimize Accell siRNA delivery conditions and control for variables in ongoing experiments with fluorescent or unlabeled positive and negative controls. Accell Control Kits combine species-specific validated controls for assessment of Accell technology in your difficult-to-transfect cells.
Cherry-pick RNAi Libraries
Fast and easy online configuration and ordering of plated siRNA & microRNA reagents targeting your genes of interest.
More...
Custom siRNA Synthesis
Use the online design tools and extensive synthesis options to create a custom siRNA specific for your application. Numerous combinations of modifications, sizes, and purification options are available for convenient online ordering.
More...
Human siRNA libraries
Human siRNA libraries are available in SMARTpool or individual siRNA format for ON-TARGETplus, siGENOME and Accell technologies. Learn more about each product line to make the right choice for your experimental needs. GE Dharmacon support more strategies for successful screening and more screening expertise than any other provider. Find the predefined gene family, including Druggable genes or Whole Genome, that's right for your discovery efforts.
Mouse siRNA Libraries
An arrayed collection of siRNA reagents for RNAi screening, targeting mouse kinases. Accell siRNA permits RNAi screening in difficult-to-transfect cells with no transfection reagent, virus, or electroporation. A wide selection of predefined siRNA libraries, including the most up-to-date Whole Mouse genome collection available.
Fast and easy online configuration and ordering of plated siRNA & microRNA reagents targeting your genes of interest.
More...
No pre-designed product to fit your needs? Use our online design tools and extensive synthesis options to create a custom siRNA specific for your application.
Preclinical scale and ORM RNA & DNA Synthesis
Midscale/OEM service for synthesis of RNA and DNA at larger quantities.
Order Custom siRNA
Order both modified or unmodified siRNAs. Patented modification patterns (ON-TARGET, ON-TARGETplus, siSTABLE, or Accell) and additional custom modifications are available.
Customer SMARTpool design & synthesis
To complement our pre-designed siRNA collections and support a broad range of RNAi experiments, our siRNA design experts can provide custom SMARTpool reagents targeting genes outside of our genomewide offerings
siDESGIN Center
Design siRNAs targeting genes in non-standard species, particular splice variants or homologous regions across gene families or species.
Lincode siRNA reagents leverage expert design tools and proprietary modifications for enhanced specificity to enable effective silencing of long noncoding RNA (lncRNA).
Cherry-pick RANi Libraries
Fast and easy online configuration and ordering of plated siRNA & microRNA reagents targeting your genes of interest.
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Custom siRNA Synthesis
Use the online design tools and extensive synthesis options to create a custom siRNA specific for your application. Numerous combinations of modifications, sizes, and purification options are available for convenient online ordering.
More...
Lincode siRNA Controls
Lincode Control siRNA reagents incorporate specificity-enhancing modifications to improve experimental results.
Lincode siRNA Libraries
Unbiased RNAi screens have become an important tool for elucidation of novel biological pathways and disease progression. The assessment of potential roles for microRNA and lncRNA, in addition to protein-coding genes, can provide a more complete picture of the genes involved in the phenotype of interest.
More...
Enjoy optimal specificity from the only siRNA with a patented modification pattern to reduce off-targets caused by either the sense or the antisense strand.
Cherry-pick RNAi Libraries
Cherry-pick from our algorithm-optimized, predesigned products lines of siRNA, microRNA, and crRNA reagents to build your own custom library.
More...
Custom siRNA Synthesis
Use the online design tools and extensive synthesis options to create a custom siRNA specific for your application. Numerous combinations of modifications, sizes, and purification options are available for convenient online ordering.
More...
Human siRNA Libraries
Human siRNA libraries are available in SMARTpool or individual siRNA format for ON-TARGETplus, siGENOME and Accell technologies. Learn more about each product line to make the right choice for your experimental needs. GE Dharmacon supports more strategies for successful screening and more screening expertise than any other provider.
Mouse siRNA Libraries
Mouse siRNA libraries are available in SMARTpool or individual siRNA format for ON-TARGETplus, siGENOME and Accell technologies. Learn more about each product line to make the right choice for your experimental needs.GE Dharmacon supports more strategies for successful screening and more screening expertise than any other provider.
ON-TARGETplus siRNA Controls
ON-TARGETplus Control siRNAs and pools are produced with the patented ON-TARGETplus modification pattern for optimal specificity. They are recommended as controls for any siRNA experiment due to their minimized off-target effects.
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siGENOME siRNAs are designed with the proprietary SMARTselection™ design algorithm for high-efficiency, guaranteed silencing. They also incorporate rational strand bias with application of ON-TARGET modifications. Highly potent siRNA for all human, mouse, and rat genes. siGENOME has provided the longest standing siRNA silencing guarantee on the market.
Cherry-pick RNAi Libraries
Cherry-pick from our algorithm-optimized, predesigned products lines of siRNA, microRNA, and crRNA reagents to build your own custom library.
More...
Custom siRNA Synthesis
Use the online design tools and extensive synthesis options to create a custom siRNA specific for your application. Numerous combinations of modifications, sizes, and purification options are available for convenient online ordering.
More...
Human siRNA Libraries
Human siRNA libraries are available in SMARTpool or individual siRNA format for ON-TARGETplus, siGENOME and Accell technologies. Learn more about each product line to make the right choice for your experimental needs. GE Dharmacon supports more strategies for successful screening and more screening expertise than any other provider.
Mouse siRNA Libraries
Mouse siRNA libraries are available in SMARTpool or individual siRNA format for ON-TARGETplus, siGENOME and Accell technologies. Learn more about each product line to make the right choice for your experimental needs.GE Dharmacon supports more strategies for successful screening and more screening expertise than any other provider.
siGENOME siRNA Controls
Controls are critical for the successful application of RNAi. Including the appropriate controls in each experiment adds certainty to the cause-and-effect relationship between gene silencing and siRNA, and aids in the distinction between target-specific and potential off-target effects.
More Products...
Dharmacon transfection reagents are designed specifically for small RNA transfection (DharmaFECT), co-transfection of plasmid and small RNA (DharmaFECT Duo), plasmid transfection (DharmaFECT kb) and self delivering siRNA for difficult to transfect cell types (Accell siRNA). A comprehensive portfolio of competitively priced, proven transfection reagents for a wide range of applications.
The most broadly applicable DharmaFECT formulation for optimal siRNA or microRNA transfection into a wide range of cell types for successful RNAi experiments. DharmaFECT 1 has been validated in over 35 cell types.
One of four siRNA/microRNA specific formulations, DharmaFECT 2 is a chemically distinct alternative to one-size-fits-all transfection reagents to achieve high-efficiency silencing in more cell types.
One of four siRNA/microRNA specific formulations, DharmaFECT 3 is a chemically distinct alternative to one-size-fits-all transfection reagents to achieve high-efficiency silencing in more cell types.
DharmaFECT 4 Transfection Reagent is chemically distinct from the other DharmaFECT formulations, providing an alternative when DharmaFECT 1 does not achieve optimal results, and is ideal to include in transfection optimization experiments prior to RNAi screening or other high-value experiments.
An aliquot of each of the four DharmaFECT formulations for siRNA/microRNA transfection optimization studies. Useful for determination of the best reagent for your cells and particular experimental conditions.
Optimized for co-transfection, DharmaFECT Duo transfection reagent provides highly effective delivery of siRNA, microRNA or crRNA reagents with plasmid. Useful for experiments utilizing reporter genes, RNAi rescue, or Edit-R Cas9 plasmid.
A unique transfection reagent from our DharmaFECT product line for introduction of DNA into cultured cells with high efficiency and low cytotoxicity.
Specially modified for delivery into difficult-to-transfect cells without a transfection reagent, Accell enables non-viral RNAi in neuronal, immune, and stem cells.
Accell siRNA Controls
Effectively optimize Accell siRNA delivery conditions and control for variables in ongoing experiments with fluorescent or unlabeled positive and negative controls. Accell Control Kits combine species-specific validated controls for assessment of Accell technology in your difficult-to-transfect cells.
Cherry-pick RNAi Libraries
Fast and easy online configuration and ordering of plated siRNA & microRNA reagents targeting your genes of interest.
Custom siRNA Synthesis
Use the online design tools and extensive synthesis options to create a custom siRNA specific for your application. Numerous combinations of modifications, sizes, and purification options are available for convenient online ordering.
Human siRNA libraries
Human siRNA libraries are available in SMARTpool or individual siRNA format for ON-TARGETplus, siGENOME and Accell technologies. Learn more about each product line to make the right choice for your experimental needs. GE Dharmacon support more strategies for successful screening and more screening expertise than any other provider. Find the predefined gene family, including Druggable genes or Whole Genome, that's right for your discovery efforts.
Mouse siRNA Libraries
An arrayed collection of siRNA reagents for RNAi screening, targeting mouse kinases. Accell siRNA permits RNAi screening in difficult-to-transfect cells with no transfection reagent, virus, or electroporation. A wide selection of predefined siRNA libraries, including the most up-to-date Whole Mouse genome collection available.
Complete your experiment with all necessary ancillary regents, including buffers, water, and specialized cell culture media.
Up-regulate or suppress endogenous mature microRNA function with rationally designed synthetic and expressed microRNA modulation reagents. Best-in-class microRNA modulation tools including miRIDIAN microRNA Mimics, microRNA Hairpin Inhibitiors and shMIMIC Lentiviral microRNAs.
Fast and easy online configuration and ordering of plated siRNA & microRNA reagents targeting your genes of interest.
Supplement endogenous microRNA activity to study gain-of-function effects. Premium design attributes promote strand-bias and enhance functionality.
Innovative microRNA inhibitor design suppresses microRNA activity to study loss-of-function effects and allows for superior potency and longevity.
The industry's most innovative mature microRNA expression system combined with latest generation of powerful Tet-inducible technology.
Tight control of microRNA expression for powerful functional screening of hundreds or thousands of microRNAs.
Expressed lentiviral microRNAs with 7 promoter and 3 reporter options for optimal, integrated expression of mature microRNAs in difficult-to-transfect cells.
Critical to any gene silencing or microRNA modulation experiment, RNAi controls enable accurate interpretation for reliable, reproducible results. Everything you need for high-quality, reproducible results. Choose from negative and positive controls as well as transfection indicators for all product lines.
Effectively optimise Accell siRNA delivery conditions and control for variable in ongoing experiments with fluorescent or unlabeled positive and negative controls. Accell Control Kits combine species-specific validated controls for assessment of Accell technology in your difficult-to-transfect cells.
Validated collection of FIPZ positive and negative controls for a well-designed RNAi experiment. Available as glycerol stocks or viral particles.
Lincode Control siRNA reagents inforporate specificity-enhancing modifications to improve experimental results. Endogenous IncRNA positive control and non-targeting control siRNA and pool reagents for high-confidence experiments.
Critical to any successful microRNA modulation experiment, the right controls enable accurate interpretation for reliable results. Choose from a collection of validated positive and negative miRIDIAN Mimic controls for use in human, mouse or rat. Fluorescently labeled controls are also available for visual tracking.
Critical to any successful microRNA modulation experiment, the right controls enable accurate interpretation for reliable results. Choose from a collection of validated positive and negative miRIDIAN Mimic controls for use in human, mouse or rat. Fluorescently labeled controls are also available for visual tracking.
Validated positive controls and non-targeting negative controls utilizing patented modifications for optimal specificity. Available as pools or single siRNAs. ON-TARGETplus Control siRNAs and pools are produced with the patented ON-TARGETplus modification pattern for optimal specificity. They are recommended as controls for any siRNA experiment due to their minimized off-target effects.
RNAi experiments in vivo requiring stabilized siRNA molecules are supported by our panel of siSTABLE controls. Choose from siSTABLE-modified controls, siRNA for silencing reporter genes (GFP, Luciferase, etc.) or other experimental needs.
A robust selection of validated positive, negative, and novel RISC-Free® controls to effectively assess all aspects of RNAi experiments. Controls are critical for the successful applications of RNAi. Including the appropriate controls in each experiment adds certainty to the cause-an-effect relationship between gene silencing and siRNA, and aids in the distinction between target-specific and potential off-target effects.
Fluorescent controls are useful for visual indication of delivery, and when combined with functional knockdown assessment, provide a useful tool for optimisation. Choose from positive control siRNAs or our novel transfection indicators.
Matched Controls enable accurate data interpretation for both SMARTvector Inducible shRNA and shMIMIC Inducible microRNAs. Inducible expression of positive and negative controls with your choice of four promoters and two reporters.
Matched Controls enable accurate data interpretation for both SMARTvector shRNA and shMIMIC microRNAs. Positive and negative shRNA controls with choice of seven promoters and two fluorescent reporters. Available for human, mouse and rat.
TRC positive and negative shRNA controls for a well-designed gene silencing experiment. Positive shRNA control targeting GFP and empty lentiviral vector negative control available as glycerol stocks.
Positive and negative TRIPZ Inducible Lentiviral shRNA Controls for setting the experimental window. Inducible shRNA positive and non-targeting negative controls are available as glycerol stock or viral particles.
Accelerate discovery with the widest selection of RNAi screening collections available. Choose from whole genome, gene families, or custom libraries.
Choose from the pre-designed product lines of shRNA and over-expression reagents to build your own custom library.
Duet siRNA Libraries offer paired siGENOME and ON-TARGETplus SMARTpool reagents in pre-defined collections for high-confidence siRNA screening. Screen them together or use them separately to support a wide range of RNAi discovery efforts.
Choose from GIPZ whole genome or gene family libraries for human or mouse. Pre-defined libraries have been assembled using innovative bioinformatic tools to reflect the most up-to-date genetic and ontological information. All libraries are offered as glycerol stocks of shRNA clones arrayed in 96-well plates. Perform genome-scale shRNA screening experiments with GIPZ Lentiviral shRNA libraries. Choose a pre-defined gene family library for smaller screening projects.
Human siRNA libraries are available in SMARTpool or individual siRNA format for ON-TARGETplus, siGENOME and Sccell technologies. learn more about each product line to make the right choice for your experimental needs. GE Dharmacon supports more strategies for successful screening and more screening expertise than any other provider.
miRIDIAN microRNA Mimic and Hairpin Inhibitor libraries are available for human, mouse and rat microRNAs in the miRBase sequence database. Libraries are packaged in 96-well plates for high-throughput screening applications. miRIDIAN tools are carefully designed to enhance functionality, specificity, and duration of action.
Mouse siRNA libraries are available in SMARTpool or individual siRNA format for ON-TARGETplus, siGENOME and Accell technologies. Learn more about each product line to make the right choice for your experimental needs. GE Dharmacon supports more strategies for successful screening and more screening expertise than any other provider.
Investigate thousands of genes with a single transduction event with powerful multiplexed screening tools.
Reverse Transfection Format (RTF) siRNA libraries are provided as multiple single-use plate sets - just rehydrate and add cells. This unique pre-plated format reduces hands-on time for faster screening results.
Choose from TRC whole genome or gene family libraries for human or mouse. Pre-defined libraries have been assembled using innovative bioinformatic tools to reflect the most up-to-date genetic and ontological information. All libraries are offered as glycerol stocks of shRNA clones arrayed in 96-well plates.
Human gene families and a genome-wide collection available with an inducible promoter for the study of essential gene function.
Enzymatically generated custom siRNA libraries for screening in non-human or mouse model organisms. Enjoy algorithm-designed siRNA produced with a novel enzymatic method to support large functional genomics studies in non-human or mouse models.
SMARTvector, GIPZ, TRIPZ and TRC lentiviral shRNA products designed for optimal gene silencing. Choose from viral vectors, viral particles or viral pools. Dharmacon lentiviral shRNA products encompass the industry's broadest, most technologically advanced portfolio of vector-based RNAi reagents for transient, long-term, inducible, and in vivo RNA interference in human, mouse, and rat cells.
Dharmacon siRNA products are the result of scientific innovation in siRNA design and novel modification strategies to optimize potency, specificity and delivery. Pre-designed genome-wide reagents for siGENOME, ON-TARGETplus, and Accell product lines. Choose highly potent siRNAs for human, mouse, and rat.
Specially modified for delivery into difficult-to-transfect cells without a transfection reagent, Accell enables non-viral RNAi in neuronal, immune, and stem cells.
No pre-designed product to fit your needs? Use our online design tools and extensive synthesis options to create a custom siRNA specific for your application.
Lincode siRNA reagents leverage expert design tools and proprietary modifications for enhanced specificity to enable effective silencing of long noncoding RNA (lncRNA).
Enjoy optimal specificity from the only siRNA with a patented modification pattern to reduce off-targets caused by either the sense or the antisense strand.
siGENOME siRNAs are designed with the proprietary SMARTselection™ design algorithm for high-efficiency, guaranteed silencing. They also incorporate rational strand bias with application of ON-TARGET modifications. Highly potent siRNA for all human, mouse, and rat genes. siGENOME has provided the longest standing siRNA silencing guarantee on the market.
Dharmacon transfection reagents are designed specifically for small RNA transfection (DharmaFECT), co-transfection of plasmid and small RNA (DharmaFECT Duo), plasmid transfection (DharmaFECT kb) and self delivering siRNA for difficult to transfect cell types (Accell siRNA). A comprehensive portfolio of competitively priced, proven transfection reagents for a wide range of applications.
The most broadly applicable DharmaFECT formulation for optimal siRNA or microRNA transfection into a wide range of cell types for successful RNAi experiments. DharmaFECT 1 has been validated in over 35 cell types.
Optimized for co-transfection, DharmaFECT Duo transfection reagent provides highly effective delivery of siRNA, microRNA or crRNA reagents with plasmid. Useful for experiments utilizing reporter genes, RNAi rescue, or Edit-R Cas9 plasmid.
The Dharmacon Trans-Lentiviral Packaging System utilizes the safest and most effective strategy for packaging virus to efficiently express your shRNA or gene of interest. Package 2nd or 3rd generation viral vectors to consistently generate high-titer viral particles for gene silencing or gene expression studies.
Package your shRNA viral vector constructs into high-titer lentiviral particles for efficient transduction and gene silencing in the cell or tissue type of interest.
Package your ORF viral vector constructs into high-titer lentiviral particles for efficient transduction and gene expression in the cell or tissue type of interest.