Single Cell Immune Profiling

Multiomic Profiling of Immune Diversity, Cell by Cell

Chromium Single Cell Immune Profiling provides a multiomic solution to your immunology questions. Analyse full length paired B-cell or T-cell receptors, surface protein expression, antigen specificity, and gene expression, all from a single cell.


  • Multiomic Cytometry - Simultaneous detection of clonality, diversity, antigen specificity, and phenotypes.
  • Complete Immune Repertoire - Paired, full-length lg sequence, including isotypes, and T-cell receptor α/β.
  • Immune Mapping - Combine immune repertoire with antigen specificity at single cell resolution.
  • Streamlined Data Analysis - Explore and visualise clonotype information with easy-to-use software.
  • One-day Lab Workflow - From sample to sequencing-ready library in one day.
  • Diverse Sample Compatibility - Demonstrated on PBMCs, fresh and frozen cell samples, and dissociated tissue.

Capabilities for Multiomic Readouts


Immune Repertoire Profiling

Understand clonal expansion and diversity by capturing full-length, paired B-cell and T-cell receptors at a single cell level.

  • Paired receptor sequence enables reexpression and testing for antigen binding and function
  • Combined with gene expression data, perform immune cell classification and discover new cell states

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Cell Surface Protein

Correlate gene expression measurements with immunophenotyping at a single cell level to better delineate immune cell subsets and functional states.

  • Enable ultra-high parameter discovery, using multiomic cytometry to detect up to hundreds of proteins simultaneously with unbiased gene expression profiling
  • Stratify immune cell populations by correlating protein isoforms with regulatory network co-expression in single cells

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Antigen Specificity

Assess the specificity of the adaptive immune system at single cell resolution with simultaneous capture of paired T cell receptors and peptide-MHC multimers, or immunoglobulin heavy and light chains and their cognate antigens.

  • Explore public and private T-cell antigen specificities using barcoded peptide-MHC multimers
  • Characterise how neoantigens may be targeted by the adaptive immune system
  • Accelerate antibody discovery with a faster and higher throughput screening technology

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