Chromium Single Cell
Visium Spatial
Instruments
Fixed RNA Profiling provides single cell whole transcriptome gene expression and multiplexing capabilities to profile hundreds to a million cells. Fixation at the point of sample collection preserves fragile biology and greatly streamlines workflows to provide critical insights on more samples.
Product Sheet: Single cell profiling on more samples with no time constraints
Profile thousands of genes at the single cell level for unbiased characterization of cell types and cell states
Product Sheet: Explore cellular diversity, cell by cell
Profile thousands of genes at the single cell level by barcoding mRNA at the 5' end, for unbiased characterisation of cell types and cell states
Product Sheet: Multiomic profiling of the immune system at single cell resolution
The first commercial single cell multiomics product for simultaneous profiling of gene expression and chromatin landscape at single cell resolution.
Capture multiple measurements simultaneously at the single cell level for deeper characterisation of cell types and states
Product Sheet: Simultaneous profiling of the transcriptome and epigenome from the same cell
Chromium Single Cell ATAC v2 is now shipping!
Chromium Single Cell Assay for Transposase Accessible Chromatin (ATAC) is a powerful method to understand gene regulation and characterise cell types and states, all at the single cell level. Building upon v1.1 chemistry, the v2 assay provides increased sensitivity and improved signal-to-noise ratio, enhancing your ability to detect rare peaks.
Product Sheet: Profiling chromatin accessibility at single cell resolution
Prep for success:
10x Genomics' new Chromium Nuclei Isolation Kit removes the complexities of nuclei isolation with an easy-to-use solution specifically designed for use with 10x Genomics single cell assays for gene expression and chromatin accessibility.
What sample types are compatible with the Chromium Nuclei Isolation Kit
Product sheet: Streamline nuclei isolation for single cell assays
10x Genomics 5' CRISPR is now available for order and shipment!
5' CRISPR Product Sheet | CRISPR Infographic | User Guide & Protocols
What is the difference between the 10x Genomics Single Cell 5' and 3' CRISPR Screening assays, and which should I use?
Our 5' CRISPR screening assay is compatible with most pre-existing Cas9 guide RNA vectors. If you have an existing CRISPR library or are starting a single cell CRISPR screen for the first time, we recommend using our Single Cell 5' v2 assay which is compatible with most guide libraries with little to no optimization required.
Our 3' CRISPR screening assay requires that a specific Capture Sequence be inserted into the vector at the appropriate location for capture of the guide. If you want to compare your single cell CRISPR experiment to data from previous experiments using 3' single cell gene expression with Feature Barcode technology, we recommend continuing to use our Single Cell 3' v3.1 assay to minimize batch effects.
A clear path to gene function with single cell CRISPR screening
Visualise gene expression within the tissue context. Available for FFPE and Fresh Frozen samples.
Gain a new perspective on tissue complexity with simultaneous gene and protein spatial profiling
Whether you're just starting out with single cell, expanding your capabilities, or seeking an automated way to partition individual cells and generate barcoded, sequencing-ready libraries, you're covered. 10x Genomics' proven Next GEM technology provides a trusted path to advance your understanding of cell diversity and function.
The most flexible way to single cell.
Expand your single cell capabilities with the most advanced hardware and highest throughput flexibility, enabling multiomic analysis of hundreds to millions of cells.
Perform multiomic analysis of hundreds to tens of thousands of single cells with this compact system.
Assay compatibility:
Combine single cell partitioning, barcoding, and/or library construction with standardised, automated workflows to maximize your productivity.
Seamlessly transition between standard histology workflows and analyte capture onto Visium slides for in-depth expression analysis.
With Visium CytAssist you can:
Workflow: Facilitate transfer of transcriptomic analytes in FFPE samples with Visium CytAssist
Product Sheet: Bridging histology and genomics
Build spatial transcriptome maps with Xenium In Situ
The Xenium workflow starts with sectioning tissues onto a microscope slide. The sections are then treated to access the RNA for labeling with circularizable DNA probes. Ligation of the probes then generates a circular DNA probe which is enzymatically amplified and bound with fluorescent oligos, creating bright, easy to image signal that has a high signal-to-noise ratio. The slide is then placed in the Xenium In Situ Analyzer where the sample then undergoes successive rounds of fluorescent probe hybridization, imaging, and removal. An optical signature specific to each gene is generated, enabling identification of the target gene. Finally, a spatial map of the transcripts is built across the entire tissue section.
About 10x Genomics is building tools for scientific discovery that reveal and address the true complexities of biology and disease.
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Established 2012
